Evaluating the potential of hyperpolarised [1-¹³C] L-lactate as a neuroprotectant metabolic biosensor for stroke.

ABSTRACT: Cerebral metabolism, which can be monitored by magnetic resonance spectroscopy (MRS), changes rapidly after brain ischaemic injury. Hyperpolarisation techniques boost ¹³C MRS sensitivity by several orders of magnitude, thereby enabling in vivo monitoring of biochemical transformations of hyperpolarised (HP) ¹³C-labelled precursors with a time resolution of seconds. The exogenous administration of the metabolite L-lactate was shown to decrease lesion size and ameliorate neurological outcome in preclinical studies in rodent stroke models, as well as influencing brain metabolism in clinical pilot studies of acute brain injury patients. The aim of this study was to demonstrate the feasibility of measuring HP [1-¹³C] L-lactate metabolism in real-time in the mous

SUBMITTER: Hyacinthe JN 

PROVIDER: S-EPMC7099080 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature