Trafficking of nonesterified fatty acids in insulin resistance and relationship to dysglycemia.

ABSTRACT: In adipose, insulin functions to suppress intracellular lipolysis and secretion of nonesterified fatty acid (NEFA) into plasma. We applied glucose and NEFA minimal models (MM) following a frequently sampled intravenous glucose tolerance test (FSIVGTT) to assess glucose-specific and NEFA-specific insulin resistance. We used total NEFA and individual fatty acids in the NEFA MM, comparing the model parameters in metabolic syndrome (MetSyn) subjects (n = 52) with optimally healthy controls (OptHC; n = 14). Results are reported as mean difference (95% confidence interval). Using the glucose MM, MetSyn subjects had lower [-73% (-82, -57)] sensitivity to insulin (S_i) and higher [138% (44, 293)] acute insulin response to glucose (AIR_g). Using the NEFA MM, MetSyn

SUBMITTER: Walker RE 

PROVIDER: S-EPMC7099405 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature