Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer's disease.

ABSTRACT: High salt (sodium) intake leads to the development of hypertension despite the fact that plasma sodium concentration ([Na⁺]) is usually normal in hypertensive human patients. Increased cerebrospinal fluid (CSF) sodium contributes to elevated sympathetic activity and high blood pressure (BP) in rodent models of hypertension. However, whether there is an increased accumulation of sodium in the CSF of humans with chronic hypertension is not well defined. Here, we investigated CSF [Na⁺] from hypertensive and normotensive human subjects with family histories of Alzheimer's disease in samples collected in a clinical trial, as spinal tap is not a routine clinical procedure for hypertensive patients. The [Na⁺] and osmolality in plasma and CSF were measured by flame

SUBMITTER: Souza LAC 

PROVIDER: S-EPMC7099411 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature