Adaptive and innate immune cell responses in tendons and lymph nodes after tendon injury and repair.

ABSTRACT: Tendon injuries are a common clinical condition with limited treatment options. The cellular components of the innate immune system, such as neutrophils and macrophages, have been studied in tendon injuries. However, the adaptive immune system, comprising specialized lymphocytes, plays an important role in orchestrating the healing of numerous tissues, but less is known about these cells in tendon healing. To gain a greater understanding of the biological processes that regulate tendon healing, we determined how the cellular components of the adaptive and innate immune system respond to a tendon injury using two-month-old male mice. We observed that lymphatic vasculature is present in the epitenon and superficial regions of Achilles tendons, and that the lymphatics drain into the popliteal

SUBMITTER: Noah AC 

PROVIDER: S-EPMC7099435 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature