Associations of Widowhood and β-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults.

ABSTRACT:

Importance

To reduce the rising incidence of clinical impairment due to Alzheimer disease, it is essential to define older adults at highest risk. Widowhood may be an unrecognized factor contributing to accelerated clinical progression along the Alzheimer disease pathway among cognitively unimpaired older adults.

Objective

To determine whether widowhood status and level of brain β-amyloid (ie, the Alzheimer disease pathologic protein) are additively or interactively associated with cognitive decline among cognitively unimpaired older adults.

Design, setting, and participants

In this cohort study, 257 married, widowed, and unmarried (ie, never married, divorced, or separated) participants from the Harvard Aging Brain Study longitudinal cohort underwent baseline evaluat

SUBMITTER: Biddle KD 

PROVIDER: S-EPMC7099624 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature