Pharmacotherapy for hypertension in Sub-Saharan Africa: a systematic review and network meta-analysis.

ABSTRACT:

Background

The highest burden of hypertension is found in Sub-Saharan Africa (SSA) with a threefold greater mortality from stroke and other associated diseases. Ethnicity is known to influence the response to antihypertensives, especially in black populations living in North America and Europe. We sought to outline the impact of all commonly used pharmacological agents on both blood pressure reduction and cardiovascular morbidity and mortality in SSA.

Methods

We used similar criteria to previous large meta-analyses of blood pressure agents but restricted results to populations in SSA. Quality of evidence was assessed using a risk of bias tool. Network meta-analysis with random effects was used to compare the effects across interventions and meta-regression to explore partici

SUBMITTER: Seeley A 

PROVIDER: S-EPMC7099775 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature