Electro-clinical and neurodevelopmental outcome in six children with early diagnosis of tuberous sclerosis complex and role of the genetic background.

ABSTRACT:

Background

Seizures in individuals affected by tuberous sclerosis complex (TSC) commonly develop in the first year of life, are often preceded by a progressive deterioration of the electroencephalogram (EEG), and likely influence developmental outcome. Although early diagnosis of TSC has offered a tremendous opportunity to monitor affected patients before seizure onset, reports of the neurological manifestations of TSC in infants before seizure onset are still scarce. Here we describe early EEG activity, clinical and genetic data and developmental assessment in a group of TSC infants, with the aim of identifying possible prognostic factors for neurodevelopmental outcome.

Methods

We report on six infants diagnosed with TSC pre- or perinatally, who underwent serial Video-EEG r

SUBMITTER: Savini MN 

PROVIDER: S-EPMC7099780 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature