Potential role of genomic imprinted genes and brain developmental related genes in autism.

ABSTRACT:

Background

Autism is a complex disease involving both environmental and genetic factors. Recent efforts have implicated the correlation of genomic imprinting and brain development in autism, however the pathogenesis of autism is not completely clear. Here, we used bioinformatic tools to provide a comprehensive analysis of the autism-related genes, genomic imprinted genes and the spatially and temporally differentially expressed genes of human brain, aiming to explore the relationship between autism, brain development and genomic imprinting.

Methods

This study analyzed the distribution correlation between autism-related genes and imprinted genes on chromosomes using sliding windows and statistical methods. The normal brains' gene expression microarray data were reanalyzed to

SUBMITTER: Li J 

PROVIDER: S-EPMC7099798 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature