Decellularized Human Dermal Matrix as a Biological Scaffold for Cardiac Repair and Regeneration.

ABSTRACT: The complex and highly organized environment in which cells reside consists primarily of the extracellular matrix (ECM) that delivers biological signals and physical stimuli to resident cells. In the native myocardium, the ECM contributes to both heart compliance and cardiomyocyte maturation and function. Thus, myocardium regeneration cannot be accomplished if cardiac ECM is not restored. We hypothesize that decellularized human skin might make an easily accessible and viable alternate biological scaffold for cardiac tissue engineering (CTE). To test our hypothesis, we decellularized specimens of both human skin and human myocardium and analyzed and compared their composition by histological methods and quantitative assays. Decellularized dermal matrix was then cut into 600-μm-thick sectio

SUBMITTER: Belviso I 

PROVIDER: S-EPMC7099865 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature