Optimization of the spatial modulation function of vessel-encoded pseudo-continuous arterial spin labeling and its application to dynamic angiography.

ABSTRACT:

Purpose

In vessel-encoded pseudo-continuous arterial spin labeling (ve-pCASL), vessel-selective labeling is achieved by modulation of the inversion efficiency across space. However, the spatial transition between the labeling and control conditions is rather gradual, which can cause partial labeling of vessels, reducing SNR-efficiency and necessitating complex postprocessing to decode the vessel-selective signals. The purpose of this study is to optimize the pCASL labeling parameters to obtain a sharper spatial inversion profile of the labeling and thereby minimizing the risk of partial labeling of untargeted arteries.

Methods

Bloch simulations were performed to investigate how the inversion profile was influenced by the pCASL labeling parameters: the maximum (G_max

SUBMITTER: Suzuki Y 

PROVIDER: S-EPMC7100033 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature