VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours.

ABSTRACT: Immune surveillance against pathogens and tumours in the central nervous system is thought to be limited owing to the lack of lymphatic drainage. However, the characterization of the meningeal lymphatic network has shed light on previously unappreciated ways that an immune response can be elicited to antigens that are expressed in the brain^1-3. Despite progress in our understanding of the development and structure of the meningeal lymphatic system, the contribution of this network in evoking a protective antigen-specific immune response in the brain remains unclear. Here, using a mouse model of glioblastoma, we show that the meningeal lymphatic vasculature can be manipulated to mount better immune responses against brain tumours. The immunity that is mediated by CD8 T cells to t

SUBMITTER: Song E 

PROVIDER: S-EPMC7100608 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature