Early and late onset pre-eclampsia and small for gestational age risk in subsequent pregnancies.

ABSTRACT:

Background

Pre-eclampsia shares pathophysiology with intrauterine growth restriction.

Objective

To investigate whether delivery of a small for gestational age (SGA) infant in the 1st pregnancy increases the risk of early and late onset pre-eclampsia in the 2nd pregnancy. Conversely, we investigated whether pre-eclampsia in the 1st pregnancy impacts SGA risk in the 2nd pregnancy.

Study design

We studied a cohort from the Dutch Perinatal Registry of 265,031 women with 1st and 2nd singleton pregnancies who delivered between 2000 and 2007. We analyzed 2nd pregnancy risks of early and late onset pre-eclampsia-defined by delivery before or after 34 gestational weeks-as well as SGA below the 5th and between the 5th and 10th percentiles risks with multivariable logistic regre

SUBMITTER: Bernardes TP 

PROVIDER: S-EPMC7100959 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature