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Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan1.

ABSTRACT: In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR34/L98H, TR34/L98H/S297T/F495I, and TR46/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment.

SUBMITTER: Wu CJ 

PROVIDER: S-EPMC7101115 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan<sup>1</sup>.

Wu Chi-Jung CJ   Liu Wei-Lun WL   Lai Chih-Cheng CC   Chao Chien-Ming CM   Ko Wen-Chien WC   Wang Hsuan-Chen HC   Dai Ching-Tzu CT   Hsieh Ming-I MI   Choi Pui-Ching PC   Yang Jia-Ling JL   Chen Yee-Chun YC  

Emerging infectious diseases 20200401 4

In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR<sub>34</sub>/L98H, TR<sub>34</sub>/L98H/S297T/F495I, and TR<sub>46</sub>/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment. ...[more]

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