Oral glucocorticoids and incidence of hypertension in people with chronic inflammatory diseases: a population-based cohort study.

ABSTRACT:

Background

Only a few population-based studies have examined the association between glucocorticoids and hypertension, with inconsistent results. We aimed to investigate the effect of oral glucocorticoids on incidence of hypertension in adults with chronic inflammatory diseases.

Methods

We analyzed electronic health records from 389 practices in England during 1998-2017 of adults diagnosed with any of 6 chronic inflammatory diseases but with no previous diagnosis of hypertension. We used glucocorticoid prescription data to construct time-variant daily and cumulative variables of prednisolone-equivalent dose (cumulated from 1 year before the start of follow-up) and estimated incidence rates and adjusted hazard ratios (HRs) for hypertension using Cox regression analysis.

Re

SUBMITTER: Mebrahtu TF 

PROVIDER: S-EPMC7101178 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature