Heterozygous rare genetic variants in non-syndromic early-onset obesity.

ABSTRACT:

Background

Obesity is a very heterogeneous disorder at both the clinical and molecular levels and with high heritability. Several monogenic forms and genes with strong effects have been identified for non-syndromic severe obesity. Novel therapeutic interventions are in development for some genetic forms, emphasizing the importance of determining genetic contributions.

Objective

We aimed to define the contribution of rare single-nucleotide genetic variants (RSVs) in candidate genes to non-syndromic severe early-onset obesity (EOO; body mass index (BMI) >+3 standard deviation score, <3 years).

Methods

Using a pooled DNA-sequencing approach, we screened for RSVs in 15 obesity candidate genes in a series of 463 EOO patients and 480 controls. We also analysed exome data fr

SUBMITTER: Serra-Juhe C 

PROVIDER: S-EPMC7101277 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature