Three-dimensional Monte Carlo-based voxel-wise tumor dosimetry in patients with neuroendocrine tumors who underwent ¹⁷⁷Lu-DOTATOC therapy.

ABSTRACT:

Background

Patients with advanced neuroendocrine tumors (NETs) of the midgut are suitable candidates for ¹⁷⁷Lu-DOTATOC therapy. Integrated SPECT/CT systems have the potential to help improve the accuracy of patient-specific tumor dosimetry. Dose estimations to target organs are generally performed using the Medical Internal Radiation Dose scheme. We present a novel Monte Carlo-based voxel-wise dosimetry approach to determine organ- and tumor-specific total tumor doses (TTD).

Methods

A cohort of 14 patients with histologically confirmed metastasized NETs of the midgut (11 men, 3 women, 62.3 ± 11.0 years of age) underwent a total of 39 cycles of ¹⁷⁷Lu-DOTATOC therapy (mean 2.8 cycles, SD ± 1 cycle). After the first cycle of therapy, regions of interest we

SUBMITTER: Goetz TI 

PROVIDER: S-EPMC7101301 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature