Transcriptomics in cancer revealed by Positron Emission Tomography radiomics.

ABSTRACT: Metabolic images from Positron Emission Tomography (PET) are used routinely for diagnosis, follow-up or treatment planning purposes of cancer patients. In this study we aimed at determining if radiomic features extracted from ¹⁸F-Fluoro Deoxy Glucose (FDG) PET images could mirror tumor transcriptomics. In this study we analyzed 45 patients with locally advanced head and neck cancer (H&N) that underwent FDG-PET scans at the time of diagnosis and transcriptome analysis using RNAs from both cancer and healthy tissues on microarrays. Association between PET radiomics and transcriptomics was carried out with the Genomica software and a functional annotation was used to associate PET radiomics, gene expression and altered biological pathways. We identified relationships between PET ra

SUBMITTER: Tixier F 

PROVIDER: S-EPMC7101432 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature