Protein modeling and molecular dynamics simulation of the two novel surfactant proteins SP-G and SP-H.

ABSTRACT: Surfactant proteins are well known from the human lung where they are responsible for the stability and flexibility of the pulmonary surfactant system. They are able to influence the surface tension of the gas-liquid interface specifically by directly interacting with single lipids. This work describes the generation of reliable protein structure models to support the experimental characterization of two novel putative surfactant proteins called SP-G and SP-H. The obtained protein models were complemented by predicted posttranslational modifications and placed in a lipid model system mimicking the pulmonary surface. Molecular dynamics simulations of these protein-lipid systems showed the stability of the protein models and the formation of interactions between protein surface and lipid hea

SUBMITTER: Rausch F 

PROVIDER: S-EPMC7101549 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature