Role of MicroRNA in Endothelial Dysfunction and Hypertension.

ABSTRACT:

Purpose of review

Hypertension is either a cause or a consequence of the endothelial dysfunction and a major risk factor for cardiovascular disease (CVD). In vitro and in vivo studies established that microRNAs (miRNAs) are decisive for endothelial cell gene expression and function in various pathological conditions associated with CVD. This review provides an overview of the miRNA role in controlling the key connections between endothelial dysfunction and hypertension.

Recent findings

Herein we summarize the present understanding of mechanisms underlying hypertension and its associated endothelial dysfunction as well as the miRNA role in endothelial cells with accent on the modulation of renin-angiotensin-aldosterone-system, nitric oxide, oxidative stress and on the control

SUBMITTER: Nemecz M 

PROVIDER: S-EPMC7102349 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature