Final adult height of children with idiopathic short stature: a multicenter study on GH therapy alone started during peri-puberty.

ABSTRACT:

Background

To evaluate the efficacy of GH in improving FAH in ISS children in a multicenter study.

Methods

A real-world observation was carried out. Children with ISS in seven hospitals in China were enrolled. The height gains standard deviation score and the height gain over the target height were evaluated.

Results

There were 344 ISS patients (217 boys and 127 girls). The baseline average age of boys and girls was 12.7 and 11.7 years, with bone age of 11.7 and 10.1 years, respectively. The baseline height SDS of boys and girls was - 3.07 and - 2.74, and the FAH SDS was - 1.91 and - 1.38, respectively. Compared with the baseline height SDS, the FAH SDS was significantly increased in both boys and girls (both P = 0.0000). The FAH SDS was the highest (gain by 1.54 SD)

SUBMITTER: Wu D 

PROVIDER: S-EPMC7102429 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature