Catalyzing the Hydrodefluorination of CF₃-Substituted Alkenes by PhSiH₃. H• Transfer from a Nickel Hydride.

ABSTRACT: The hydrodefluorination of CF₃-substituted alkenes can be catalyzed by a nickel(II) hydride bearing a pincer ligand. The catalyst loading can be as low as 1 mol%. gem-Difluoroalkenes containing a number of functional groups can be formed in good to excellent yields by a radical mechanism initiated by H• transfer from the nickel hydride. The relative reactivity of various substrates supports the proposed mechanism, as does a TEMPO trapping experiment.

SUBMITTER: Yao C 

PROVIDER: S-EPMC7102444 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature