In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus.

ABSTRACT:

Objective

In this study we execute a rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel coronavirus (2019-nCoV), an ongoing novel coronavirus that causes pneumonia.

Methods

There were two main steps in the screening process. In the first step we conducted a literature search for natural compounds that had been biologically confirmed as against sever acute respiratory syndrome coronavirus or Middle East respiratory syndrome coronavirus. Resulting compounds were cross-checked for listing in the Traditional Chinese Medicine Systems Pharmacology Database. Compounds meeting both requirements were subjected to absorption, distribution, metabolism and exc

SUBMITTER: Zhang DH 

PROVIDER: S-EPMC7102521 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature