Functional effects of variation in transcription factor binding highlight long-range gene regulation by epromoters.

ABSTRACT: Identifying DNA cis-regulatory modules (CRMs) that control the expression of specific genes is crucial for deciphering the logic of transcriptional control. Natural genetic variation can point to the possible gene regulatory function of specific sequences through their allelic associations with gene expression. However, comprehensive identification of causal regulatory sequences in brute-force association testing without incorporating prior knowledge is challenging due to limited statistical power and effects of linkage disequilibrium. Sequence variants affecting transcription factor (TF) binding at CRMs have a strong potential to influence gene regulatory function, which provides a motivation for prioritizing such variants in association testing. Here, we generate an atlas of CRMs showing

SUBMITTER: Mitchelmore J 

PROVIDER: S-EPMC7102942 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature