Functional polymorphisms in FOXC2 gene and Epithelial ovarian Cancer susceptibility in Chinese population.

ABSTRACT:

Background

Epithelial ovarian cancer (EOC) is highly lethal gynecological cancer. Forkhead Box Protein C2 (FOXC2) promotes occurrence and development of various malignant tumors. The present study is aimed at exploring the correlation between the polymorphism of FOXC2 and epithelial ovarian cancer susceptibility in Chinese Han population.

Methods

A case-control design was used to verify the association between FOXC2 polymorphisms and epithelial ovarian cancer. The genotyping was performed using Taqman® SNP Genotyping kit by qRT-PCR. The genetic variants including rs3751794 C > T, rs1035550 A > G, rs4843163 C > G and rs4843396 C > T in FOXC2 gene were analyzed. The strength of the associations was detected using odds ratios and 95% confidence intervals. Stratification analyse

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC7103066 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature