Targeting the porcine immune system--particulate vaccines in the 21st century.

ABSTRACT: During the last decade, the propagation of immunological knowledge describing the critical role of dendritic cells (DC) in the induction of efficacious immune responses has promoted research and development of vaccines systematically targeting DC. Based on the promise for the rational design of vaccine platforms, the current review will provide an update on particle-based vaccines of both viral and synthetic origin, giving examples of recombinant virus carriers such as adenoviruses and biodegradable particulate carriers. The viral carriers carry pathogen-associated molecular patterns (PAMP), used by the original virus for targeting DC, and are particularly efficient and versatile gene delivery vectors. Efforts in the field of synthetic vaccine carriers are focussing on decorating the parti

SUBMITTER: McCullough KC 

PROVIDER: S-EPMC7103233 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature