Effect of Thyroxine Therapy on Depressive Symptoms Among Women With Subclinical Hypothyroidism.

ABSTRACT:

Objective

To estimate the effect of antenatal treatment of subclinical hypothyroidism on maternal depressive symptoms.

Methods

We conducted an ancillary study to a multicenter trial in women with singleton pregnancies diagnosed with subclinical hypothyroidism randomized to antenatal thyroxine therapy or placebo. Treatment was discontinued at the end of pregnancy. Women with overt thyroid disease, diabetes, autoimmune disease, and those diagnosed with depression were excluded. Participants were assessed for depressive symptoms using the Center for Epidemiological Studies-Depression scale (CES-D) before starting the study drug (between 11 and 20 weeks of gestation), between 32 and 38 weeks of gestation, and at 1 year postpartum. The primary outcome was maternal depressive symp

SUBMITTER: Costantine MM 

PROVIDER: S-EPMC7103482 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature