The Thalamocortical Circuit of Auditory Mismatch Negativity.

ABSTRACT:

Background

Mismatch negativity (MMN) is an extensively validated biomarker of cognitive function across both normative and clinical populations and has previously been localized to supratemporal auditory cortex. MMN is thought to represent a comparison of the features of the present stimulus versus a mnemonic template formed by the prior stimuli.

Methods

We used concurrent thalamic and primary auditory cortical (A1) laminar recordings in 7 macaques to evaluate the relative contributions of core (lemniscal) and matrix (nonlemniscal) thalamic afferents to MMN generation.

Results

We demonstrated that deviance-related activity is observed mainly in matrix regions of auditory thalamus, MMN generators are most prominent in layer 1 of cortex as opposed to sensory responses t

SUBMITTER: Lakatos P 

PROVIDER: S-EPMC7103554 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature