Towards uterus tissue engineering: a comparative study of sheep uterus decellularisation.

ABSTRACT: Uterus tissue engineering may dismantle limitations in current uterus transplantation protocols. A uterine biomaterial populated with patient-derived cells could potentially serve as a graft to circumvent complicated surgery of live donors, immunosuppressive medication and rejection episodes. Repeated uterine bioengineering studies on rodents have shown promising results using decellularised scaffolds to restore fertility in a partially impaired uterus and now mandate experiments on larger and more human-like animal models. The aim of the presented studies was therefore to establish adequate protocols for scaffold generation and prepare for future in vivo sheep uterus bioengineering experiments. Three decellularisation protocols were developed using vascular perfusion through the uterine a

SUBMITTER: Tiemann TT 

PROVIDER: S-EPMC7103571 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature