Association of G6PD variants with hemoglobin A1c and impact on diabetes diagnosis in East Asian individuals.

ABSTRACT:

Objective

Hemoglobin A1c (HbA1c) accuracy is important for diabetes diagnosis and estimation of overall glycemia. The G6PD-Asahi variant which causes glucose-6-phosphate dehydrogenase (G6PD) deficiency has been shown to lower HbA1c independently of glycemia in African ancestry populations. As different G6PD variants occur in Asian ancestry, we sought to identify Asian-specific G6PD variants associated with HbA1c.

Research design and methods

In eight Asian population-based cohorts, we performed imputation on the X chromosome using the 1000 Genomes reference panel and tested for association with HbA1c (10 005 East Asians and 2051 South Asians). Results were meta-analyzed across studies. We compared the proportion of individuals classified as having diabete

SUBMITTER: Leong A 

PROVIDER: S-EPMC7103857 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature