Indexing brain state-dependent pupil dynamics with simultaneous fMRI and optical fiber calcium recording.

ABSTRACT: Pupillometry, a noninvasive measure of arousal, complements human functional MRI (fMRI) to detect periods of variable cognitive processing and identify networks that relate to particular attentional states. Even under anesthesia, pupil dynamics correlate with brain-state fluctuations, and extended dilations mark the transition to more arousable states. However, cross-scale neuronal activation patterns are seldom linked to brain state-dependent pupil dynamics. Here, we complemented resting-state fMRI in rats with cortical calcium recording (GCaMP-mediated) and pupillometry to tackle the linkage between brain-state changes and neural dynamics across different scales. This multimodal platform allowed us to identify a global brain network that covaried with pupil size, which served to generate

SUBMITTER: Pais-Roldan P 

PROVIDER: S-EPMC7104268 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature