CD29 identifies IFN-γ-producing human CD8⁺ T cells with an increased cytotoxic potential.

ABSTRACT: Cytotoxic CD8⁺ T cells can effectively kill target cells by producing cytokines, chemokines, and granzymes. Expression of these effector molecules is however highly divergent, and tools that identify and preselect CD8⁺ T cells with a cytotoxic expression profile are lacking. Human CD8⁺ T cells can be divided into IFN-γ- and IL-2-producing cells. Unbiased transcriptomics and proteomics analysis on cytokine-producing fixed CD8⁺ T cells revealed that IL-2⁺ cells produce helper cytokines, and that IFN-γ⁺ cells produce cytotoxic molecules. IFN-γ⁺ T cells expressed the surface marker CD29 already prior to stimulation. CD29 also marked T cells with cytotoxic gene expression from different tissues in single-cell RNA-seque

SUBMITTER: Nicolet BP 

PROVIDER: S-EPMC7104308 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature