Men1 maintains exocrine pancreas homeostasis in response to inflammation and oncogenic stress.

ABSTRACT: A more comprehensive understanding of the molecular mechanisms underlying pancreatic diseases, including pancreatitis and cancer, is essential to improve clinical management. MEN1 has established roles in epigenetic regulation and tumor suppression in the endocrine pancreas; however, intriguing recent data suggest MEN1 may also function in the exocrine pancreas. Using physiologically relevant genetic mouse models, we provide direct evidence that Men1 is essential for exocrine pancreas homeostasis in response to inflammation and oncogenic stress. Men1 loss causes increased injury and impaired regeneration following acute caerulein-induced pancreatitis, leading to more severe damage, loss of the normal acinar compartment, and increased cytokeratin 19-positive metaplasias and immune cell infi

SUBMITTER: Wasylishen AR 

PROVIDER: S-EPMC7104337 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature