DNA origami protection and molecular interfacing through engineered sequence-defined peptoids.

ABSTRACT: DNA nanotechnology has established approaches for designing programmable and precisely controlled nanoscale architectures through specific Watson-Crick base-pairing, molecular plasticity, and intermolecular connectivity. In particular, superior control over DNA origami structures could be beneficial for biomedical applications, including biosensing, in vivo imaging, and drug and gene delivery. However, protecting DNA origami structures in complex biological fluids while preserving their structural characteristics remains a major challenge for enabling these applications. Here, we developed a class of structurally well-defined peptoids to protect DNA origamis in ionic and bioactive conditions and systematically explored the effects of peptoid architecture and sequence dependency on DNA orig

SUBMITTER: Wang ST 

PROVIDER: S-EPMC7104344 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature