CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness.

ABSTRACT: A role for microglia in neuropsychiatric diseases, including major depressive disorder (MDD), has been postulated. Regulation of microglial phenotype by immune receptors has become a central topic in many neurological conditions. We explored preclinical and clinical evidence for the role of the CD300f immune receptor in the fine regulation of microglial phenotype and its contribution to MDD. We found that a prevalent nonsynonymous single-nucleotide polymorphism (C/T, rs2034310) of the human CD300f receptor cytoplasmic tail inhibits the protein kinase C phosphorylation of a threonine and is associated with protection against MDD, mainly in women. Interestingly, CD300f^-/- mice displayed several characteristic MDD traits such as augmented microglial numbers, increased interleukin 6

SUBMITTER: Lago N 

PROVIDER: S-EPMC7104369 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature