Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment.

ABSTRACT:

Background

The role of sex hormones on cellular function is unclear. Studies show androgens and estrogens are protective in the CNS, whereas other studies found no effects or damaging effects. Furthermore, sex differences have been observed in multiple oxidative stress-associated CNS disorders, such as Alzheimer's disease, depression, and Parkinson's disease. The goal of this study is to examine the relationship between sex hormones (i.e., androgens and estrogens) and oxidative stress on cell viability.

Methods

N27 and PC12 neuronal and C6 glial phenotypic cell lines were used. N27 cells are female rat derived, whereas PC12 cells and C6 cells are male rat derived. These cells express estrogen receptors and the membrane-associated androgen receptor variant, AR45, but not the

SUBMITTER: Duong P 

PROVIDER: S-EPMC7104511 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature