Association between the IL-10 and IL-6 polymorphisms and brucellosis susceptibility: a meta-analysis.

ABSTRACT: BACKGROUND:Brucellosis is a quite normal zoonotic infection, which is caused by immediate contact with animals infected with Brucella or its products. IL-10 (-?1082?G/A, -?819 C/T, -?592C/A) and IL-6 -174?G/C polymorphisms have a great relationship with IL-10 and IL-6 production, which brings about Brucellosis pathogenesis and development. So far, the results of published literatures were controversial. Now, we perform a meta-analysis in different ethnic populations to get a more precise estimate of above polymorphisms with Brucellosis susceptibility. METHODS:Both OR and corresponding 95%CI were enrolled to make an assessment of the association strength through extracting genotyping frequency of cases and controls. The ?2-test based Q-statistic and I2 statistics were applied. If there was no evident heterogeneity, the fixed-effects model would be applied. If not, the random-effects model would be used. RESULTS:The significant associations were only found in Asian population of -?819 loci under three genetic models as follows: (Allele model: OR?=?0.60, 95%CI?=?0.44-0.82, P?=?0.001), (homozygote comparison: OR?=?0.24, 95%CI?=?0.09-0.62, P?=?0.003), (recessive genetic model: OR?=?0.22, 95%CI?=?0.05-0.91, P?=?0.036). CONCLUSION:In conclusion, IL-10?-?819 loci polymorphism contributes no risk to Caucasian population but may be associated with decreased risk in Asian population. And IL-10 -1082?G/A, 592 loci and IL-6 -174?G/C polymorphism are not associated with Brucellosis risk.

SUBMITTER: Jin X 

PROVIDER: S-EPMC7104517 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature