Factors associated with the prescribing of high-dose opioids in primary care: a systematic review and meta-analysis.

ABSTRACT:

Background

The risks of harms from opioids increase substantially at high doses, and high-dose prescribing has increased in primary care. However, little is known about what leads to high-dose prescribing, and studies exploring this have not been synthesized. We, therefore, systematically synthesized factors associated with the prescribing of high-dose opioids in primary care.

Methods

We conducted a systematic review of observational studies in high-income countries that used patient-level primary care data and explored any factor(s) in people for whom opioids were prescribed, stratified by oral morphine equivalents (OME). We defined high doses as ≥ 90 OME mg/day. We searched MEDLINE, Embase, Web of Science, reference lists, forward citations, and conference proceedings from

SUBMITTER: Richards GC 

PROVIDER: S-EPMC7104520 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature