HLA-G14bp ins/del polymorphism and post-transplant weight gain in kidney transplantation: potential implications beyond tolerance.

ABSTRACT:

Background

Human leukocyte antigen (HLA)-G is a non-classical HLA molecule with immunomodulant and immunosuppressive functions, involved in transplantation tolerance. HLA-G14bp ins/del polymorphism in exon 8 has been associated with allograft rejection and kidney transplant outcome, with controversial results. We investigated associations of HLA-G14bp ins/del polymorphism on onset of some of the main post-transplant risk factors, like excess body weight, lipid abnormalities, increased fasting plasma glucose. Polymorphisms of cytokines with both immunosuppressive and metabolic effects were also assessed for comparisons and associated analysis.

Methods

The present study involved kidney transplant recipients (n = 173) in which body mass index, cholesterol, triglycerides, fastin

SUBMITTER: Piancatelli D 

PROVIDER: S-EPMC7104538 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature