Microbial burden and viral exacerbations in a longitudinal multicenter COPD cohort.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by frequent exacerbation phenotypes independent of disease stage. Increasing evidence shows that the microbiota plays a role in disease progression and severity, but long-term and international multicenter assessment of the variations in viral and bacterial communities as drivers of exacerbations are lacking.

Methods

Two-hundred severe COPD patients from Europe and North America were followed longitudinally for 3 years. We performed nucleic acid detection for 20 respiratory viruses and 16S ribosomal RNA gene sequencing to evaluate the bacterial microbiota in 1179 sputum samples collected at stable, acute exacerbation and follow-up visits.

Results

Similar viral and bacteria

SUBMITTER: Bouquet J 

PROVIDER: S-EPMC7104712 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature