Microstructure and Mechanical Property of Glutaraldehyde-Treated Porcine Pulmonary Ligament.

ABSTRACT: There is a significant need for fixed biological tissues with desired structural and material constituents for tissue engineering applications. Here, we introduce the lung ligament as a fixed biological material that may have clinical utility for tissue engineering. To characterize the lung tissue for potential clinical applications, we studied glutaraldehyde-treated porcine pulmonary ligament (n = 11) with multiphoton microscopy (MPM) and conducted biaxial planar experiments to characterize the mechanical property of the tissue. The MPM imaging revealed that there are generally two families of collagen fibers distributed in two distinct layers: The first family largely aligns along the longitudinal direction with a mean angle of θ = 10.7 ± 9.3 deg, while the second one exhibits a random d

SUBMITTER: Chen H 

PROVIDER: S-EPMC7104758 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature