Regional increases in brain signal variability are associated with pain intensity reductions following repeated eccentric exercise bouts.

ABSTRACT:

Background

Traditional pain interventions limit fluctuations in pain sensation, which may paradoxically impair endogenous pain modulatory systems (EPMS). However, controlled exposures to clinically relevant pain (e.g. delayed onset muscle soreness [DOMS]) may build capacity in the EPMS. Emerging evidence suggests that regional signal variability (RSV) may be an important indicator of efficiency and modulatory capacity within brain regions. This study sought to determine the role of RSV in both susceptibility to and trainability of pain response following repeated DOMS inductions.

Methods

Baseline and follow-up resting-state fMRI was performed on 12 healthy volunteers ~40 days apart. Between scanning visits, participants received four weekly DOMS inductions in alternating elb

SUBMITTER: Boissoneault J 

PROVIDER: S-EPMC7104905 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature