NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription.

ABSTRACT: Long noncoding RNAs (lncRNAs) modulate various biological processes, but their role in host antiviral responses is largely unknown. Here we identify a lncRNA as a key regulator of antiviral innate immunity. Following from the observation that a lncRNA that we call negative regulator of antiviral response (NRAV) was dramatically downregulated during infection with several viruses, we ectopically expressed NRAV in human cells or transgenic mice and found that it significantly promotes influenza A virus (IAV) replication and virulence. Conversely, silencing NRAV suppressed IAV replication and virus production, suggesting that reduction of NRAV is part of the host antiviral innate immune response to virus infection. NRAV negatively regulates the initial transcription of multiple critical inter

SUBMITTER: Ouyang J 

PROVIDER: S-EPMC7104942 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature