Semisynthesis and Biological Evaluation of Platensimycin Analogues with Varying Aminobenzoic Acids.

ABSTRACT: Platensimycin (PTM) is an excellent natural product drug lead against various gram-positive pathogens, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. In this study, twenty PTM derivatives with varying aminobenzoic acids were semisynthesized. In contrast to all the previous reported inactive aminobenzaote analogues, a few of them showed moderate antibacterial activities against S. aureus. Our study suggested that modification of the conserved aminobenzoic acid remains a viable approach to diversify the PTM scaffold.

SUBMITTER: Tian K 

PROVIDER: S-EPMC7105086 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature