Identification of Stevens-Johnson syndrome and toxic epidermal necrolysis in electronic health record databases.

ABSTRACT:

Background

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) carry a high mortality risk. While identifying clinical and genetic risk factors for these conditions has been hindered by their rarity, large electronic health databases hold promise for identifying large numbers of cases for study, especially with the introduction in 2008 of ICD-9 codes more specific for these conditions.

Objective

The objective of this study is to estimate the validity of ICD-9 codes for ascertaining SJS/TEN in 12 collaborating research units in the USA, covering almost 60 million lives.

Methods

From the electronic databases at each site, we ascertained potential cases of SJS/TEN using ICD-9 codes. At five sites, a subset of medical records was abstracted and standardize

SUBMITTER: Davis RL 

PROVIDER: S-EPMC7105169 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature