Human Endometrial Transcriptome and Progesterone Receptor Cistrome Reveal Important Pathways and Epithelial Regulators.

ABSTRACT: Poor uterine receptivity is one major factor leading to pregnancy loss and infertility. Understanding the molecular events governing successful implantation is hence critical in combating infertility. To define Progesterone Receptor (PGR)-regulated molecular mechanisms and epithelial roles in receptivity. RNA-sequencing and PGR-ChIP-seq were conducted in parallel to identify PGR-regulated pathways during the Window of implantation (WOI) in endometrium of fertile women. Endometrial biopsies from the proliferative and mid-secretory phases were analyzed. Participants were fertile, reproductive aged (18-37 years) women with normal cycle length, and without any history of dysmenorrhea, infertility, or irregular cycles. In total, 42 endometrial biopsies obtained from 42 women were analyzed in th

SUBMITTER: Chi RA 

PROVIDER: S-EPMC7105253 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature