Profiling the expression and function of oestrogen receptor isoform ER46 in human endometrial tissues and uterine natural killer cells.
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ABSTRACT:
SUBMITTER: Gibson DA
PROVIDER: S-EPMC7105323 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
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Profiling the expression and function of oestrogen receptor isoform ER46 in human endometrial tissues and uterine natural killer cells.
Gibson Douglas A DA Esnal-Zufiaurre Arantza A Bajo-Santos Cristina C Collins Frances F Critchley Hilary O D HOD Saunders Philippa T K PTK
Human reproduction (Oxford, England) 20200301 3
<h4>Study question</h4>Does the oestrogen receptor isoform, ER46, contribute to regulation of endometrial function?<h4>Summary answer</h4>ER46 is expressed in endometrial tissues, is the predominant ER isoform in first trimester decidua and is localised to the cell membrane of uterine natural killer (uNK) cells where activation of ER46 increases cell motility.<h4>What is known already</h4>Oestrogens acting via their cognate receptors are essential regulators of endometrial function and play key ...[more]
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