Disrupted-in-schizophrenia 1 functional polymorphisms and D₂ /D₃ receptor availability: A [¹¹ C]-(+)-PHNO imaging study.

ABSTRACT: The disrupted-in-schizophrenia 1 (DISC1) protein has been implicated in a range of biological mechanisms underlying chronic mental disorders such as schizophrenia. Schizophrenia is associated with abnormal striatal dopamine signalling, and all antipsychotic drugs block striatal dopamine 2/3 receptors (D_2/3 Rs). Importantly, the DISC1 protein directly interacts and forms a protein complex with the dopamine D₂ receptor (D₂ R) that inhibits agonist-induced D₂ R internalisation. Moreover, animal studies have found large striatal increases in the proportion of D₂ R receptors in a high affinity state (D₂^high R) in DISC1 rodent models. Here, we investigated the relationship between the three most common polymorphisms alt

SUBMITTER: Dahoun T 

PROVIDER: S-EPMC7105392 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature