A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood.

ABSTRACT: BACKGROUND:The prenatal period is a period of vulnerability during which neurotoxic exposures exert persistent changes in brain development and behavior. Polybrominated diphenyl ethers (PBDEs), used as flame retardants in commercial products, are known to be developmental neurotoxicants. PBDEs were phased out of use in the United States a decade ago, but exposure remains widespread due to their release from existing products and biopersistence. Despite consistent animal and epidemiological evidence of developmental neurotoxicity, the neural substrates linking prenatal PBDE serum concentrations to impaired neurodevelopment are poorly understood. METHODS:In the present study, we used resting state functional magnetic resonance imaging (fMRI) to examine associations between prenatal PBDE conc

SUBMITTER: de Water E 

PROVIDER: S-EPMC7105394 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature