The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis.

ABSTRACT: Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 controls of East Asian and European ancestries. We discover two previously unreported loci, NFKB1 (rs230540, OR = 1.25, P = 3.4 × 10^-12) and IRF4 (rs9405192, OR = 1.29, P = 1.4 × 10^-14), fine-map the PLA2R1 locus (rs17831251, OR = 2.25, P = 4.7 × 10^-103) and report ancestry-specific effects of three classical HLA alleles: DRB1*1501 in East Asians (OR = 3.81, P = 2.0 × 10^-49), DQA1*0501 in Europeans (OR = 2.88, P = 5.7 × 10^-93), and DRB1*0301 in both ethnicities (OR = 3.50, P = 9.2 × 10^-23 and OR = 3.39, P = 5.2 × 10^-82, respectively). GWAS loci

SUBMITTER: Xie J 

PROVIDER: S-EPMC7105485 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature