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Nuclear Factor ?B (NF-?B)-Mediated Inflammation in Multiple Sclerosis.

ABSTRACT: The nuclear factor ?B (NF-?B) signaling cascade has been implicating in a broad range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. The past three decades have witnessed a great progress in understanding the impact of aberrant NF-?B regulation on human autoimmune and inflammatory disorders. In this review, we discuss how aberrant NF-?B activation contributes to multiple sclerosis, a typical inflammatory demyelinating disease of the central nervous system, and its involvement in developing potential therapeutic targets.

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7105607 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Nuclear Factor κB (NF-κB)-Mediated Inflammation in Multiple Sclerosis.

Zhou Yifan Y   Cui Chunping C   Ma Xiaoyu X   Luo Wenjing W   Zheng Song Guo SG   Qiu Wei W  

Frontiers in immunology 20200324

The nuclear factor κB (NF-κB) signaling cascade has been implicating in a broad range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. The past three decades have witnessed a great progress in understanding the impact of aberrant NF-κB regulation on human autoimmune and inflammatory disorders. In this review, we discuss how aberrant NF-κB activation contributes to multiple sclerosis, a typical inflammatory demyelinating disease of the central n  ...[more]

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